What would you do to defend the Spread Offense? I would mix it up more defensively I think. One thing that I would do is have six guys close to the line of scrimmage and tell them to really knock the guys going out for passes off their routes and make them pay before they get into their route. That would give the rushers time to get to the QB and you would possibly tire out the WR's and RB's a little more. Too many times I see players just get off the line of scrimmage too easily and it is much easier for a passing team to get into the rhythm when they aren't knocked off their route from the start. That would be something I would try at least for a series to see if it worked.
Any other ideas?