LinkAn adviser to Ukraine's Interior Ministry said a Malaysia Airlines passenger plane carrying more than 200 people crashed Thursday while flying over the east Ukraine region of Donetsk.
Malaysia Airlines confirmed it had lost contact with Flight MH17 and its last known position was over Ukrainian airspace.
Malaysia Airlines Flight 17 departed from Amsterdam around noon on Thursday and was due to arrive in Kuala Lumpur early Friday.
The plane went down near the city of Torez in the Donetsk region while flying at a height of about 10,000 meters, according to Anton Gerashchenko, an adviser to Ukraine's Interior Ministry.
Unconfirmed reports are saying it was shot down.