This is my line of work - started 20+ years ago and yes, times have changed. No lunches or time with docs doing fun stuff, and HIPPA and the AMA (it's not the affordable care act that impacted pharma, it's the medical groups banding together to track spending of industry, and it happened long before ACA).
The numbers of sales team members has been cut dramatically since the 2009 or so - I was part of a huge sales force (Abt 10k) that is down to maybe 2k now and I heard they're going through layoffs again. I joined a small company awhile ago and it's much better, but that too has it's own tradeoffs. Because of all the shrinkage of the last 10 years most "entry level" will be a contract sales force. Companies can take their pick of tenured, talented sales people looking for work and wouldn't take a chance on a clinician who has no sales experience when they can get them.
Why is he wanting to make this change? He should be ready to answer that candidly, and have a purpose. The old "to have more flexibility" will get him booted from the hiring managers short list immediately. The biggest concern will be if he can sell. Unless he has experience of cold calling and numbers and he's really serious about this I'd say he should also be looking to take a year or two in a sale job to get those skills prior to interviewing.
Id say to make the transition I'd focus on the arena he was a specialist for - looking at oxygen sales or an asthma and allergy company. He better be ready to work in a team environment. As entry level he'd likely be calling on a territory where at least two other reps overlap him, and the model is frequency on docs. Teach above mentioned how easy the work is and how much money you make (as well as a number of other stereotypical comments) and while hard work can equal a good payday the bonus' are not like they used to be, and I'd have to know where he lives regionally, but without experience his salary would probably be better than some lines of work, but certainly below 60k. (Teach if your buddy was working 20 hours a week and playing golf I can tell you why he was let go, and why it took him 10 years to find a new gig).
Device sales might be an option if he can get aligned to a respiratory company - typically entry level with those companies are on call 24/7 and weekends, and work in a team of 2-3 members where they split bonus.
Many people have a limited (and uneducated) view of what we do. I'd tell him to connect with the reps who come to visit him now and network with them to understand how his skills might transfer, and if he'd really like the job. Ask if he can spend time with them over coffee discussing the job and requirements. The travel. Depending on the territory many of us have to commit to 40-60% travel on average, so he should be ok with being away from home on overnights a couple times a week and then for meetings quarterly.
Lots of info and I've barely scratched the surface. My q would be after all the schooling and training why would he want to leave RT?