Texas at Nebraska, Oct. 16.
Why it's big: Cornhuskers should be undefeated heading into what could be their only game of the regular season against a ranked opponent -- unless Texas keeps losing and drops out of the Top 25, rendering Nebraska's long-awaited Game of the Year a huge anticlimax.
Why it's interesting: See the aforementioned Game of the Year mention. And see the original Red Out Around the World video and logo from the summer. And see the way the 2009 Big 12 championship game ended. Nebraskans like to maintain that they're much too polite to be out for blood -- but rest assured, they're out for blood.
Who will win: Texas, 13-12.