I believe that any scheme will work if you execute. However the more things you can throw at the oppossing defense and their coaches the more they have to work in practice and film studyconcerning themselves at stopping all of the weapons a offense has.
If you run a spread option offense for example there is alot schemes you as a "D" coordinator have to concern yourself with.
Never a fan of the WCO in college. It was a fad in the 90's and didn't work and most teams abadoned it.
In order to get playmakers the ball in space.
But I think execution is the key, Lombardi and the Bear reportedly would not run a play in a game if it wasn't run in practice like 300 times.
Once you perfect it, I don't think it matters what you run, see TO in the 90's.