Anything can work offensively in the Big 10. Case in point - The amount of yards TCU put up against Ohio State a couple weeks ago. TCU's offense is actually a pretty good example of what I think Frost wants this offense to be - tons of speed, tons of spreading the field out wide, then gashing you with deep throws. They put up 511 yards against a very physical and fast defense in Ohio State. In fact, this type of offense (meaning TCU's) actually creates a good mismatch against many Big 10 teams.
Defensively is a different topic, in my opinion. You have to choose the right scheme to play defense well in this conference and you have to coach a run-first mentality. Bo was hot and cold in this department, but ultimately it was the biggest thing that burned him.