Ghana and the US are probably pretty evenly matched right now. The US should be a better team, but it's hard to credit them with that as they've been so inconsistent. Still, I have to give the US a better shot at winning this game.
A little history...the US was put out of the last WC by Ghana, and that certainly hasn't been forgotten.
Donovan is of course one to watch on the US side, but I would also keep an eye on Alditore. His work off the ball against Algeria was fantastic.
On the defensive side, the main thing to watch for is if our defenders keep focused the entire game. They have a tendency to fall asleep now and then and it has cost us in the past. We need to come out of the gate playing our best against Ghana and not slip back into the sluggishness we often show during the first 15 minutes.