I think eventually we will see super conferences, 4 to be exact, 16 in each conference. Truly that is where the real competition shuts off at. 16 set up regionally, center is in St Louis, and have Northwest, Northeast, south east and south west. I know it will not end up like that but, keep regional traditions alive. Meaning Penn State is not in conference with USC. I think the Big is already headed in that direction and the SEC is to. 16 gives you a conference championship game, 4 Conference champions, 4 team play off.
I have no solid idea of who the conferences would be made up with, but close to existing now. ACC would be absorbed by Big an SEC and the Big 12 would merge with the Pac 12 in some aspects, hell Texas wants that now.
I see the 64 select teams breaking away from the NCAA for their own upper division level. Not in my lifetime, but truly think they the big conferences are already moving towards it.