I'd just look at every facet of the game. For starters, Oregon wasn't a very good team last year. I also don't think they're going to be very good on defense this year for a variety of reasons. I don't suspect that will change this weekend. Advantage: Nebraska.
Culture and program stability. Oregon is in a full transition year. Nebraska made some big changes this offseason too, but if I had to give a slight advantage to one team over another, I'd go advantage: Nebraska.
Offense. Both teams have a lot of weapons. Oregon has a more established running back and a more polished offensive strategy. I think running the ball is going to be critical for both teams, but I'd give Oregon: advantage.
Special Teams. I don't know much about Oregon's. Nebraska's was pretty bad in 2016, but they showed a lot of good things in week one. I'd put this as a wash for now.
So, depending on your perspective, Nebraska has a 2-1-1 advantage in these four categories. If I've misjudged Oregon's ST, then it might be a 2-2 split. Either way, I think this should be a good contest and wouldn't be surprised to see it turn out like last year's game.