My personal opinion about the running game is to run power out of the spread. That may sound like an oxymoron, but it's really not. Power is a blocking scheme associated with pulling guards, assignment blocking, and using a fullback (when under center) or H-back (when in a shotgun or pistol) as a lead blocker.
This is what Ohio St was doing in the playoffs last year. They killed Bama/Oregon with the same power play all night long. It was a beauty to watch.
I agree that it was a beauty to watch, but the blocking scheme was actually a zone. See the center would point out the middle of the opponents defense. Usually a MLB, but it could also be a nose guard when going against a 3-4 defense. The left guard and tackle would double team the D lineman immediately to the left of the center's middle guy, but the guard would only hold him long enough for the tackle to engage and then move ahead to block the second level. The backside DE would be taken care of by the H-back who would go from the play side to the backside and seal it off. The QB would read the unblocked backside OLB. If the OLB moved towards the middle, the QB would run the ball outside. If the OLB stayed outside, he would hand it off to the HB, who would find the best running lane in the middle where they had 4 blockers (LG, C, RG, and RT) on four defenders (RDT, RDE, ROLB, MLB). Elliot would just hit the hole and be gone. Almost every time they ran that play, it was a Safety that made the tackle. It was a beautifully designed and very well executed play, but it was a zone play. Sure, it had elements of power, but at its heart it was a zone play.