Why would anyone want a big win for and even bigger lose? That just doesn't even make sense. You don't become champions by losing games like that.. just plain silly!
Because in the scenario pointed out by the OP, the big win has a larger absolute value than the loss does. You beat a top 5 ranked OSU, and then you lose a close game to an Illinois/Maryland, with all the rest of the games on the schedule going the way they 'should' go on paper, that is a net positive gain by a long shot.
Ohio State lost to Virginia Tech in 2014. I'm wondering how in the hell they became champions? If this question were posed to them, without guarantee of the playoffs, what do you think their answer would be? "Would you be okay with losing to sh**ty Virginia Tech but then beating #7 MSU, or #11 Wisc, or #1 Bama, or #2 Oregon, with all the rest of the games going the way they should go?" They'd be pretty stupid to answer the way almost everyone in this thread is answering.
Reality is, unless people have it all, they'll be unhappy with what they do have. Under Pelini we were pissed because we'd get to 9-10 wins against lowly competition, and then sh#t the bed against the top teams. Now under Riley, we've done a 180 of sorts, getting pissed that we're putting up a much better fight and actually being able to knock off some really good teams, but then dropping some we shouldn't.
As far as my answer, I'm okay with anything. I don't lose sleep or become unhappy if we lose a game no matter who it's against. It's entertainment, folks. I'm along for the ride, hoping they win every game, but having a blast cheering for my team either way.