I've mostly found that you can't go deep over the middle with any kind of post route because if you do it's going to get picked off or deflected. Also just in playing the game I've found about 50% of my incompletions come from dropped passes. Some are understandable, the receiver getting lit up and such, but some it seems like the littlest taps make them drop the ball.
Didn't play NCAA '11 at all, but I put a ton of time into Madden '11 and I had absolutely none of the problems that I'm having with this game (outside of the dropped balls, but I worked my way around it in Madden).