I would think that Frost's system (simplified) would work well in Nebraska HS football. There are big linemen in Nebraska, just not every team has a full line of them. So, I would think that a more spread out offense would work with teams that have good athletes, just not a big over powering line. It would benefit the good athletes that teams have.
I'm told that it's a relatively simple system also. It's not like a bunch of rout trees and rout options that you have to be next to an NFL QB to understand. So, the limited practice time HSs have could make this work.