We definitely rotated our OL more over the past few years than most teams do. And I see Cav's point about chemistry because that is important as well.
But I don't think subbing a guy or two for a series here and there is going to totally destroy the chemistry. And it would let a couple top backups get some chemistry with the rest of the starters in case he has to be a starter at some point.
I'm all for playing the best guys most of the time but saying only the best guys should play completely ignores the fatigue factor. One guy might be better when he is 100% but if he's tired later in the game and is only going at, say, 85-90%, perhaps a fresh backup is better. Or if you give him a rest at some point in the game maybe he's still running 95% at the end.
And I think it's interesting that we have such different philosophies on the two sides of the ball. We rotate defensive linemen all the time. It's a regular occurrence that we sub someone on the DL after the first play of a possession. If we want the best players to play, shouldn't that be true on the DL as well?
I guess bottom line for me is I don't necessarily have an issue with it, but I think it would make sense in a lot of ways to rotate a little bit. Maybe give each guard and tackle one series off per half. I probably wouldn't rotate the center.