Frazier's run vs. Florida is by far my favorite.
However, I'll add Kareem Moss' INT at the end of the 94 Orange Bowl that sealed it. When Schlesinger scored his 2nd TD, there were still 2 minutes left. Costa completed a short pass, and was sacked twice, leading to 4th-and-19. When Moss made the INT, it was a feeling of release of all the near-misses and past failures, a feeling of joy and validation and redemption and glory.